Hi to all,
I have one really big problem, I am creating a software to detect aneuploidies from whole genome sequencing. At first I filtrate noise data, after that I separate genome to each bin with 60kb size. For now I have a tables where is information about coordinates of bin, gc content in bin for reads and number of reads. For now I have to do correction of number of reads to GC. Could you please help with this? Why I have to do it and what equation I have to use?