Question: Software for power analysis in meta-analysis: compute the maximum significance needed by an additional sample for meta-analysis to reach genome-wide significance
gravatar for lillo.sim
5.6 years ago by
United Kingdom
lillo.sim40 wrote:

I have an association study analysis (GWAS) that does not reach genome-wide significance (max p-value <10E-5), and there is a potential additional sample (so with known N and known effect size/SE for each association) that we want to use together with the GWAS to conduct a fixed effect meta-analysis. However before including this sample I am looking for a power analysis (an R package preferably) that can help me understand the maximum significance level that this additional sample would have to reach for the meta-analysis to reach genome-wide significance. I am not even sure this question can be answered, can anyone please point me to any R packages or software that can help with power analysis for fixed-effect meta-analysis?

Thank you in advance for your suggestions


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