I'm working on a blood pressure genetics project and have got a bit stuck. I am trying to analyse data to see if there are genetic associations between systolic and diastolic bp and several outcomes. I have external weights from the published literature to make my genetic profile scores in Plink. However, some of the effects/betas are associated with an increase in bp, whilst others are associated with a decrease in bp. Someone has suggested that I re-code alleles in the SNP data, so that they are 0,1,2 increasing blood pressure, rather than leaving them coded as the minor allele. However, I'm not sure exactly what this means, in terms of actually re-coding in any of my Plink files. I don't know which Plink file I'd be recoding the 0,1,2 in and what exactly to...
Any tips/advice would be much appreciated!