Question: identification of oncogenes
0
gravatar for rohit.bioinfo.11
6.5 years ago by
rohit.bioinfo.1110 wrote:

I have a question about gene identification as oncogene involved in cancer.whether a gene is targeted or regulated by an oncomir can we consider that gene as an oncogene or there is any other way to identify a gene ?

gene • 2.1k views
ADD COMMENTlink modified 6.5 years ago by Devyani30 • written 6.5 years ago by rohit.bioinfo.1110

It's somewhat difficult to parse your question. Are you asking how one determines whether a gene is an oncogene or not?

ADD REPLYlink written 6.5 years ago by Devon Ryan98k

yes

ADD REPLYlink modified 19 months ago by _r_am32k • written 6.5 years ago by rohit.bioinfo.1110
3
gravatar for Devyani
6.5 years ago by
Devyani30
India
Devyani30 wrote:

When an oncomir (over-expressing miRNA causing cancer) is over-expressed it will target a gene which will be a tumor suppressor gene. When a tumor suppressor miRNA ( down-regulated miRNA causing cancer) is down-regulated its target gene is over-expressed which is called an oncogene. So any gene whose over-expression causes cancer is called an oncogene. The over-expression can be due to any reason like down-regulation of the miRNA which targets it or other epigenetic factors, etc. 

ADD COMMENTlink written 6.5 years ago by Devyani30
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