Coming from a non-bio background, this stuff can get confusing to me. Some time ago I asked about what chip-seq is when applied to TFs but now my question is related to histone modifications.
I understand that the method to sequence TF binding sites is essentially take cells where the transcription factors are bound, "freeze" them, cut out the rest of the DNA and sequence whats left. However I don't see how this method applies to histone modifications. There are no "proteins" that bind to histones, am I correct? so how can we sequence "binding sites" for histones, if that even makes sense.
As you can see, I probably will need a little introduction to what histone modifications really are. I think this YouTube video helped greatly (and in the vocabulary that I can understand) but I feel like I need more information. Wikipedia is very confusing at my level of understanding.
So what are histone modifications and how can be sequence them using Chip-Seq metthods.
