hello
I have a question while i am reading a paper that is related to a gene fusion discovery.
below is some of the paper's content.
A paired end read will be a member of multiple valid clusters as a result of homology between genes, exon redundancy between transcripts, and the multiplicity of valid clusterings. Fusion events are rare when compared with the event of detecting a discordant paired end read given the existence of a fusion event that would generate that read. Thus we seek an assignment of each paired end read to a single fusion event (valid cluster) that minimizes the number of fusion events.
(Valid cluster represents a potential fusion event implied by a set of discordant alignments)
i don't understand the bold text. I think the verb "minimizes" should be changed to "maximizes " because
It maybe increase the number of gene fusion by calculating the single paired end read to a single gene fusion.
I hope you understand my basic questions. I'm beginner in this field.
Anyway I am looking forward to your reply.
Thank you.
Thank you!
I appreciate a your answer and it gave me a insight to this field.