I have a question while i am reading a paper that is related to a gene fusion discovery.
below is some of the paper's content.
A paired end read will
be a member of multiple valid clusters as a result of homology
between genes, exon redundancy between transcripts, and the
multiplicity of valid clusterings. Fusion events are rare when
compared with the event of detecting a discordant paired end read
given the existence of a fusion event that would generate that read.
Thus we seek an assignment of each paired end read to a single
fusion event (valid cluster) that minimizes the number of fusion
(Valid cluster represents a potential fusion event implied by a set of discordant alignments)
i don't understand the bold text. I think the verb "minimizes" should be changed to "maximizes " because
It maybe increase the number of gene fusion by calculating the single paired end read to a single gene fusion.
I hope you understand my basic questions . I'm beginner in this field.
Anyway I am looking forward to your reply.