Hi all ,
One of our collaborators has sequenced the exome of a cancer patient with a rare cancer disease (JMML).I have analysed the exome sequences using the mercury pipeline already. (https://www.hgsc.bcm.edu/software/mercury)
We further analysed high coverage data for selected cancer genes and found some single nucleotide variants as well. I was wondering what computational/informatics aspect can I incorporate in this work. I know the question is kind of absurd but I would appreciate if someone can provide me some pointers .
Like if they have been involved in such analysis and what sort of biological questions can be asked which can be explored from computational perspective using additional public data since its only a single sample (and also a reduced genelist high coverage sample).