Question: Target genes of transcriptional factors from co-expression networks
0
gravatar for pixie@bioinfo
4.7 years ago by
pixie@bioinfo1.4k
pixie@bioinfo1.4k wrote:

This might be a bit lame question. I have built a co-expression network from gene expression data. I observed that the network contains many transcription factors. If I consider a transcription factor, will any of its first-degree neighbour (which has a high correlation value with the transcription factor) give me any idea what are the target genes of that factor ? I have seen a few papers highlighting the first neighbours of TFs but I am not sure why they do this. Any view on this will be greatly appreciated.

ADD COMMENTlink modified 4.7 years ago by Devon Ryan89k • written 4.7 years ago by pixie@bioinfo1.4k
1
gravatar for Devon Ryan
4.7 years ago by
Devon Ryan89k
Freiburg, Germany
Devon Ryan89k wrote:

Yeah, the most strongly correlated genes, which would presumably become first-degree neighbors if you did things correctly, are likely targets. This isn't definitive of course, but it'd be a smart starting place.

ADD COMMENTlink written 4.7 years ago by Devon Ryan89k

Thanks Devon !

ADD REPLYlink written 4.7 years ago by pixie@bioinfo1.4k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1491 users visited in the last hour