I am interested in the distribution of protein numbers regulation by transcription factor (TF) based on TF PWM matrix. Specifically, the strength of regulation effects on downstream genes computed based on Position Weighted Matrix.
I have read the paper
Further, I propose to use this information to infer the probability of regulation relationship between TF and gene. As I known, besides PWM matching other factors play crucial roles as well, such as post translation modification, environment conditions. So, based solely on this data, to what extend could we believe the performance of this method.
Thanks a lot!