I tried to normalize my count table in DESeq which SizeFactor of them are:
N1 S1 S2 0.9936395 0.9606483 1.0525232
It happened because S2 has much more aligned reads (in bam file) in contrast with other 2 samples.
What should I do to normalize S2 in DESeq? How can I use normalization to make them close?