How is the WGSIM read simulator used to sequence a simulated genome at 5X haploid coverage?
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7.7 years ago
zhangz.cs ▴ 280

What is haploid coverage? What argument is used to control producing haploid coverage instead of diploid coverage?

I know the -h option can enable the haploid mode, but I can't understand what the haploid mode really means. I hope someone can help me to answer these questions. Thanks!

Best Regards,
Zhen

genome sequencing • 2.2k views
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Entering edit mode
7.7 years ago

haploid coverage: there is only one copy of a chromosome: you should only get homozygotes ALT variants.