Question: Is there an information source that lists the differences between clonal and parallel evolution w.r.t cancer?
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gravatar for murali
5.4 years ago by
murali100
Germany
murali100 wrote:

What are the significant differences between clonal and parallel evolution w.r.t cancer?

cancer • 1.3k views
ADD COMMENTlink modified 5.4 years ago by Manvendra Singh2.1k • written 5.4 years ago by murali100

Can you add some background to your question? Or what led you to this line of inquiry? For example, are you looking for a tool that can model the heterogeneity of a given sample? Or do you simply want to discuss this topic at a high level? From my understanding, clonal/parallel simply describe the width/depth of a cancer's phylogenetic tree. Here's a good read.

ADD REPLYlink modified 5.4 years ago • written 5.4 years ago by Cyriac Kandoth5.5k
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gravatar for Manvendra Singh
5.4 years ago by
Manvendra Singh2.1k
Berlin, Germany
Manvendra Singh2.1k wrote:

In clonal evolution, metastasis represents the end stage of evolution, where firstly, tumor mass is occupied by malignant cells containing genomic alterations, these alterations causes transformation of malignant to metastatic stage (e.g. Colorectal Cancers).
In Parallel evolution, Metastasis occurs at early stage and so the primary and metastatic tumous evolve parallely (e.g. Epithelial tumous)


> I would recommend to read these papers

http://www.ncbi.nlm.nih.gov/pubmed/12892707?dopt=Abstract
clincancerres.aacrjournals.org/cgi/ijlink?linkType=ABST&journalCode=pnas&resid=100/13/7737
http://www.ncbi.nlm.nih.gov/pubmed/15170447?dopt=Abstract
clincancerres.aacrjournals.org/cgi/ijlink?linkType=ABST&journalCode=pnas&resid=99/4/2246
http://www.ncbi.nlm.nih.gov/pubmed/16169467?dopt=Abstract

 

 

ADD COMMENTlink written 5.4 years ago by Manvendra Singh2.1k
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