Entering edit mode
13.1 years ago
Wjeck ▴ 490
I just looked over the SliderII preprint in Bioinformatics and I'm wondering if anyone has had good experience with it. I'm impressed with their mapping technique, especially since I am working in the human genome where many SNPs have already been annotated. I'm a little worried that it won't work well for very high coverage since they don't appear to discuss that in their paper (on a cursory look).
Has anyone used SliderII with deep coverage, particularly with deep coverage of Illumina reads?
I have not read this paper yet, but it does seem strange that it would work worse if the read coverage were high.
does the paper have comparisons with existing aligners? there have been some recent papers and seems novoalign is really good.. eland2 is up there as well