Sliderii For Deep Coverage
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14.2 years ago
Wjeck ▴ 490

I just looked over the SliderII preprint in Bioinformatics and I'm wondering if anyone has had good experience with it. I'm impressed with their mapping technique, especially since I am working in the human genome where many SNPs have already been annotated. I'm a little worried that it won't work well for very high coverage since they don't appear to discuss that in their paper (on a cursory look).

Has anyone used SliderII with deep coverage, particularly with deep coverage of Illumina reads?

sequencing short aligner snp • 2.4k views
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I have not read this paper yet, but it does seem strange that it would work worse if the read coverage were high.

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does the paper have comparisons with existing aligners? there have been some recent papers and seems novoalign is really good.. eland2 is up there as well

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