Question: About Punnett Squares
1
gravatar for Zhshqzyc
9.3 years ago by
Zhshqzyc490
Zhshqzyc490 wrote:

Hello,

I have a stupid question for Punnett Squares. For example, let us define "A" as being the dominant normal allele and "a" as the recessive abnormal one. As carriers, you and your mate are both heterozygous (Aa). This disease only afflicts those who are homozygous recessive (aa).

My question: Is "A" or "a" just pronoun? "A" may come from one of "A", "G", "C", "T"? "a" also may come from one of "A", "G", "C", "T"?

So "Aa" is just a combination of two letters of "A","G","C" and "T"? "AA" or "aa" is just one of "AA","GG","CC" and "TT"?

Thanks.

gene off genotyping • 2.1k views
ADD COMMENTlink modified 7.3 years ago by Biostar ♦♦ 20 • written 9.3 years ago by Zhshqzyc490
2

This is a bioinformatics forum so this question is a bit off topic. I don't think you understand the difference between alleles (Aa) and nucleotides (ACGT)

ADD REPLYlink written 9.3 years ago by Ying W4.0k
5
gravatar for Charles E. Grant
9.3 years ago by
Seattle
Charles E. Grant220 wrote:

The alleles in Punnett Squares represent a higher level of abstraction then a simple base change. They can represent just about any variation in a genome that is linked to a clear phenotype. They might represent a single base change, or they might represent insertions, deletions, inversions or copy numbers variations. A and a are just labels for two different versions of some portion of the genome.

ADD COMMENTlink written 9.3 years ago by Charles E. Grant220
1

I've no idea, since I don't know anything about plink. If your question is really about the specific use of Punnett Squares in plink then you should edit your question to reflect that.

ADD REPLYlink written 9.3 years ago by Charles E. Grant220

Thank you very much. For the plink analysis http://pngu.mgh.harvard.edu/~purcell/plink/data.shtml#ped Can we say an allele is jsut a nucleotide coincidently?

ADD REPLYlink modified 14 months ago by _r_am31k • written 9.3 years ago by Zhshqzyc490
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