I have a list of N genes. I used DAVID (http://david.abcc.ncifcrf.gov) in order to get the GO terms that are statistically overrepresented in that list. I selected the GO_BP_FAT subset of terms to not take in account some really generic GO terms (high level terms in the GO tree). Surprisingly I found out something unclear. Given a specific GO term I have a list of genes (defined by DAVID) that should be statistically associated with that term. Now, if I query the Gene Ontology database using the "official" AMIGO interface (http://amigo1.geneontology.org/) I found that the GO term indicated by DAVID is not associated with some genes. For example I found that PAX3, with other genes, is associated with GO:004582, but if you query Amigo you don't get this term. How is this possible?
Question: David enrichment analysis inconsistency
6.3 years ago by
ncl.lazzarini • 120
ncl.lazzarini • 120 wrote:
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