**510**wrote:

Hi All,

I have a data set ~20000 observations, and when I plot the histogram for this data,I found it skewed to the right. I used log transformation, but I got infinity values because I have many values equal to zero. Is there any way to use the log transformation without removing these zero values because it's important in my analysis. Or is there any other to transformation this data.

**9.2k**• written 6.1 years ago by M K •

**510**

We add 1 to RNA-seq counts for all the transcripts before the log transformation to get rid of the negative values.

12kso this will not effect the results at all.

510