Uses of HMMER in bioinformatics

Question

[medhi_banani]

I am a CSE student and I am entitled a project on running Hmmer on MIC Architecture. For this, I have started reading HMMER and what it does. What I am unable to comprehend is, why and where is protein sequence alignment and identifying protein homologous necessary?

Answer 1

[Manvendra Singh]

When you get homologous regions from allignment across the families or species, then they are Conserved domains.Conserved domains in proteins play a crucial role in protein interactions, DNA binding, enzyme activity, and other important cellular processes.

I mean they are very very important for survival.

Please read some review article regarding this.