Entering edit mode
9.5 years ago
mangfu100
▴
800
Hi.
As the post title, what is reciprocal partners?
I see that this name comes along with gene fusion.
To understand better, look at this example below.
all 14 fusions involving ALK or ROS1 were either experimentally confirmed or represent a reciprocal partner of a validation fusion, we considered all such events true positive.
Like above sentence, we can confirm gene fusion as true positive by experimental approach or reciprocal partner.
I knew why experimental approach give a true positive, but cannot connect same thing regarding reciprocal partner.
Can you give me more information or help?
Reciprocal partners are the genes that are fused with your target gene as far as I can tell, so that would the gene that fused with ALK and/or ROS1.
My interpretation is that if they used experimental methods, but if it represented the other fusion then they would use that without validation.
They validated one of these and then considered them both true positives.
Does that make any sense.
Thank you for your answer :)
So you state that not both of two genes but just only one gene appears during experimental validation process, then
It is also called gene fusion case.
Right?
Yep as my goto simplest explanation, the other possibility is that it is a fusion, which was validated in another tumour already so they decided not to do it again and just called it a true positive.
However, to me a reciprocal partner gene means they traded DNA, just like the philadelphia chromosome is a reciprocal chromosomal translocation. Which means if you validated one, you then got the other one for free.
http://en.wikipedia.org/wiki/Philadelphia_chromosome