Question: How many of the human reference sequence alleles are derived alleles?
1
gravatar for humanevo1
4.4 years ago by
humanevo110
United States
humanevo110 wrote:

What percentage of the human reference sequence is thought to be identical to what we believe the ancestral human sequence looked like? To put it another way, if I'm looking at a SNP in an individual, and they differ from the human reference sequence at that site, how likely is it that the SNP in the individual is the derived allele? 

I'm thinking someone should have calculated this somewhere using primate outgroups to do the portions of the genome with high primate homology, but I can't find any papers that mention this. 

 

ADD COMMENTlink modified 4.4 years ago by Katie D'Aco1000 • written 4.4 years ago by humanevo110
1
gravatar for Katie D'Aco
4.4 years ago by
Katie D'Aco1000
Massachusetts
Katie D'Aco1000 wrote:

Check out the paper Initial sequence of the chimpanzee genome and comparison with the human genome it might have what you're looking for. From the first page: 

"Single-nucleotide substitutions occur at a mean rate of 1.23% between copies of the human and chimpanzee genome, with 1.06% or less corresponding to fixed divergence between the species."

ADD COMMENTlink written 4.4 years ago by Katie D'Aco1000
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 2391 users visited in the last hour