Job:Postdoctoral Fellow / Researcher in Bioinformatics, Haukeland University Hospital, Bergen, Norway.
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8.2 years ago
chtzoulis ▴ 30

Group: Translational Science in Neurodegeneration and Aging (TSNA)

Position: Postdoctoral Fellow / Researcher in Bioinformatics

A full-time position as postdoctoral fellow / researcher is vacant for an initial period of two years with possibility for extension, starting as soon as possible, at the Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Job Description:

Parkinson's disease (PD) is a major cause of death and disability. It affects ~2% of the population above the age of 65 and its prevalence is increasing as the population ages reaching ~4% above the age of 85 years. The etiology of PD is unknown and despite good symptomatic treatments, there is no cure and patients die prematurely due to progressive disability. These studies aim to elucidate the pathogenesis of PD at the genetic, epigenetic and molecular level and use this knowledge to identify novel therapeutic targets.

The candidate will be leading a fully funded research project aiming at elucidating novel genetic, epigenetic and molecular mechanisms in the pathogenesis of Parkinson's disease with a main focus on mitochondrial function. The studies are based on a unique material from large (>2000), homogenous and extensively characterized patient groups.

Main tasks will include integrative and innovative analyses of large-scale data sets including data from whole exome sequencing, targeted re-sequencing, SNP-chip arrays and genome-wide DNA methylation.

The candidate will work closely with the PI, one other postdoc, and a PhD student employed on this project. The TSNA group includes both clinicians and basic scientists devoted to the study of neurodegenerative disorders. We have well-equipped laboratory facilities and full access to bioinformatics labs with state-of-the-art analysis tools. We also have access to a wide array of university platforms covering microscopy, metabolomics, transcriptomics and proteomics.

The candidate will interact directly with a highly competitive and stimulating research environment including neurologists, pathologists, geneticists and bioinformaticians.

This position is ideal for candidates interested in highly translational research in the field of aging and neurodegeneration. This post will offer substantial opportunities for career development and growth.

For further information about the project and the position, please contact

Dr Charalampos Tzoulis, e-mail:, Tel +47 55975058; or +47 55975045 (Departmental office).


  • We are seeking a talented scientist with expertise in advanced bioinformatic analyses, already holding a PhD or equivalent degree to drive this project.
  • Experience in integrative hypothesis-free and hypothesis-based analyses of large unbiased datasets, such as whole-exome sequencing data, is required.
  • Additional experience in analyses of epigenetic information (e.g. methylome) will be prioritised.
  • Experience in mitochondrial genetics is an advantage.
  • The candidate should be proficient in spoken and written English.


  • High scientific ambition, determination, and the desire for innovation and impact will be emphasized.
  • Personal skills will be emphasized. The candidate should be able to work independently and interactively in a team setting, be motivated and responsible, and also have a strong commitment and enthusiasm for research.

We can offer

  • An excellent work environment in a research group that is at the forefront of its field
  • A highly competitive starting salary and further promotion after service seniority in the position.
  • A good pension scheme in the Norwegian Public Service Pension Fund.
  • Outside work, Bergen offers an extensive range of facilities for both cultural and leisure activities.

How to apply

You can apply by submitting the following information to

  • Cover letter stating your motivation for the position
  • Current curriculum vitae with a complete review of education and professional experience
  • Complete list of publications
  • Two references (name and contact information)

Application deadline 15/12/2014

mitochondria next-gen-sequencing genome Parkinson • 3.1k views

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