Measure Tag Snps, R Package, Tools
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10.1 years ago
Cirrus ▴ 40

Dear all,

is there any tool, which I can run on my local computer or R package to measure r^2 (LD) and identify tag SNPs?

I found tagger from the Broad Institue, but this is a web service. I need a local tool. coz I have a lot of data sets.

Many thanks for any hinds.

r snp selection linkage • 3.1k views
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10.1 years ago

HaploView and HelixTree are what we routinely use to perform this. These are superior stand-alone tools for this work.

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Thanks a lot, I will use Haploview!!

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3.4 years ago
zx8754 10k

PriorityPruner

http://prioritypruner.sourceforge.net/

PriorityPruner is a software program which can prune a list of SNPs that are in high linkage disequilibrium (LD) with other SNPs in the list, while preferentially keeping/selecting SNPs of higher priority (e.g., the most significant SNPs in a genome-wide association study).

Input:

  1. A genotype dataset (e.g., PLINK format)
  2. A table of SNPs annotated with p-values or other prioritization criteria

Output:

  1. A table of SNPs with columns indicating if the SNP is selected and/or tagged by a selected SNP
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