general question about "intra tumor heterogeneity"
2
0
Entering edit mode
9.8 years ago
imagineyd ▴ 70

Dear All,

I wonder that there are references or any literature about "intra tumor heterogeneity" in cancer types.

Are there some discussion or evidences which cancer type shows the most heterogeneity or vise verse?

Any kinds of comments are very welcome :)

Thanks!

cancer-type heterogeneity • 2.2k views
ADD COMMENT
2
Entering edit mode
9.8 years ago

The short answer is that in most tumor types, most tumors display some amount of subclonal heterogeneity. It's everywhere, and low-frequency events are not being well captured in our standard 50-100x tumor assays.

Update: I can tell you from personal experience that when looking at close to 1000 exomes from TCGA, most (60%+) have detectable subclonal mutations, and I'd wager that most of the rest just didn't have sufficient coverage to uncover additional low-VAF populations. Very few tumors are actually monoclonal.

ADD COMMENT
0
Entering edit mode

If you're looking for specific cross-cancer comparisons of subclonal mutations, you could do worse than some of the work that my colleagues at TGI did here: http://www.nature.com/nature/journal/v502/n7471/full/nature12634.html

ADD REPLY
1
Entering edit mode
9.8 years ago
a.polo88 ▴ 120

I think that you can start with these two references:

but I agree with chris miller

ADD COMMENT

Login before adding your answer.

Traffic: 1770 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6