Question: general question about "intra tumor heterogeneity"
0
gravatar for imagineyd
4.3 years ago by
imagineyd70
Spain
imagineyd70 wrote:

Dear All,

 

I wonder that there are references or any literatures about "intra tumor heterogeneity" in cancer types.

Are there some discussion or evidences which cancer type shows the most heterogeneity or vise verse?

 

Any kinds of comments are very welcome :)

 

Thanks!!

 

cancer type heterogeneity • 1.2k views
ADD COMMENTlink modified 4.3 years ago by a.polo88100 • written 4.3 years ago by imagineyd70
2
gravatar for Chris Miller
4.3 years ago by
Chris Miller20k
Washington University in St. Louis, MO
Chris Miller20k wrote:

The short answer is that in most tumor types, most tumors display some amount of subclonal heterogeneity. It's everywhere, and low-frequency events are not being well captured in our standard 50-100x tumor assays.

Update: I can tell you from personal experience that when looking at close to 1000 exomes from TCGA, most (60%+) have detectable subclonal mutations, and I'd wager that most of the rest just didn't have sufficient coverage to uncover additional low-VAF populations.  Very few tumors are actually monoclonal.

ADD COMMENTlink modified 4.3 years ago • written 4.3 years ago by Chris Miller20k

If you're looking for specific cross-cancer comparisons of subclonal mutations, you could do worse than some of the work that my colleagues at TGI did here: http://www.nature.com/nature/journal/v502/n7471/full/nature12634.html

ADD REPLYlink written 4.3 years ago by Chris Miller20k
1
gravatar for a.polo88
4.3 years ago by
a.polo88100
Italy
a.polo88100 wrote:

i think that you can start with these two references :

http://www.nejm.org/doi/full/10.1056/nejmoa1113205

http://www.sciencedirect.com/science/article/pii/S0304419X09000742(payment try to search free)

but i'm agree with chris miller

ADD COMMENTlink written 4.3 years ago by a.polo88100
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