I am working with a breast cancer dataset called METABRIC. It contains p53 sequencing information like so:
I would greatly appreciate the community's feedback. I want to understand, so that I can cross-reference these mutations with databases.
This is what I think I understand: there is a cytosine that is inserted after an adenosine which causes a frameshift. This frameshift causes the 178th amino acid (histidine) to be converted into a proline. If so, I assume that the remaining codons will be different. I am also confused about what ex5,6+7519122 +12521 mean.
Thank you very much for your time.