Tool:Discovering protein-lncRNA interactions from large-scale CLIP-Seq and TCGA Cancer datasets
Entering edit mode
7.7 years ago
lsp03yjh ▴ 830

We had released RBP-lncRNA Platform to decode interaction between lncRNAs and RNA-binding proteins (RBPs) by mining 111 CLIP-Seq (PAR-CLIP, HITS-CLIP, iCLIP, CLASH, eCLIP, irCLIP) datasets.

RBP-lncRNA platform provides the following Analysis Services:

  1. **We provide interactive web-page to display the 22,735 RBP-lncRNA regulatory relationships identified from 117 CLIP-Seq datasets generated by 50 independent studies.
  2. We also revealed the expression correlation of RBP-lncRNA interaction networks by mining expression profiles of over 6000 normal and tumor samples from 14 cancer types.
  3. We found that one single lncRNA will generally be bound and regulated by one or multiple RBPs, the combination of which may coordinately regulate gene expression.
  4. We discovered hundreds of disease-related single nucleotide polymorphisms (SNP) resided in the RBP binding sites of lncRNAs.

The paper has been published in Front Bioeng Biotechnol. 2015;2:88.

RBP-lncRNA Interaction web site:

RBP-lncRNA interactions are supported by co-expression analysis in 14 types of cancers.

< image not found >

cancer CLIP-Seq RBP lncRNA RNA-Seq • 4.0k views

Login before adding your answer.

Traffic: 1668 users visited in the last hour
Help About
Access RSS

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6