Question: can ihs/ehh be applied on specific geographic region population?
0
gravatar for evo_genomics
4.2 years ago by
evo_genomics40
Pakistan
evo_genomics40 wrote:

can ihs/ehh be applied on a specific geographic region population (i.e African Population) for selection estimation?  or can it be applied to mixture of all populations (Asian, African Europe America )?

which of these two methods will be more logical.

thanks

ADD COMMENTlink modified 4.2 years ago by Zev.Kronenberg11k • written 4.2 years ago by evo_genomics40
1
gravatar for Zev.Kronenberg
4.2 years ago by
United States
Zev.Kronenberg11k wrote:

Within population measures are more reasonable. 

 

ADD COMMENTlink written 4.2 years ago by Zev.Kronenberg11k

Yes, using homogeneous population is more sensible, however you should also take into account the number of samples in your dataset. Simulations have shown that these tests maintain power with sample sizes of ca. 40 chromosomes or above. If you have similar populations (say geographically similar as you asked) you can lump them together to increase power, however if they are different is better to use them separately.

ADD REPLYlink written 4.1 years ago by GabrielMontenegro520
1

Two comments: 1:"similar" is a slippery slope.  2: you also loose power by lumping together populations that do not share the same selective sweeps. 

ADD REPLYlink written 4.1 years ago by Zev.Kronenberg11k
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