Question: Is protein structure prediction with low query coverage an appropriate method?
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4.0 years ago by
evo_genomics30
Pakistan
evo_genomics30 wrote:

I am studying the evolutionary aspect of gene family. I want to build the structure of each family member and want to estimate, how much paralogs (family members) are related or distant from each other at structural level.

But I found very low query coverage of target (family member) with template i.e:

Member A:  Identity: 30% Query Coverage:49%

Member B:  Identity: 33% Query Coverage:49%

Member C:  Identity: 31% Query Coverage:52%

Template is available for N terminal of target protein whereas no template is available for C terminal of target protein.

Query coverage and identity of N terminal with target is :

Identity: 35% Query Coverage:91%

I want to Know whether I can build a reliable protein structure for family members using an abinito approach. I am interested in construction of structure for whole protein.

I will be grateful

structure abinito protein • 1.1k views
ADD COMMENTlink modified 4.0 years ago • written 4.0 years ago by evo_genomics30
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