I downloaded the Denisova BAM file from here: ftp://cdna.eva.mpg.de/denisova/alignments/T_hg19_1000g.bam
Since this file is aligned to the 1000 genomes reference genome and I would like to align it to grch38 I started the following utility for BAM to FASTQ conversion http://gsl.hudsonalpha.org/information/software/bam2fastq
After the file converted the FASTQ file is about 180GB whereas the BAM file is 80GB.
My question is does this seem correct and is there a way to estimate the size of FASTQ from a BAM file?
If there is faster converter please could you share, thanks in advance.