Question: Selection of a "suggestive" level of association in a GWAS study
gravatar for Vincent Laufer
4.0 years ago by
Vincent Laufer1.0k
United States
Vincent Laufer1.0k wrote:

In GWAS studies, 5*10-8 seems the defacto standard for association. A lesser known threshhold is 1*10-5.

This threshhold is often called "suggestive association."

I am writing to ask, where did this figure come from? Were empirical tests or statistical simulations done to select this level? 

I can find many papers that USE this level, but far fewer that JUSTIFY it. Any relevant citations would be welcome, and thank you.

statistics association gwas • 2.6k views
ADD COMMENTlink written 4.0 years ago by Vincent Laufer1.0k
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