Impact of mutations in conserved and non-conserved regions - !?

Question

[muralinmars]

Dear All,

I have this explanation for mutations occuring in conserved and non-conserved regions. Will be great if someone can correct me if wrong and add some more to it..

SNPs in non-conserved regions - can get lost in subsequent generations and not so important.

SNPs in conserved regions - are vital (as the region by itself is more important and conserved through evolutionary pressure), but it is highly likely that they can get removed under natural selection. If that is the case how can those SNPs be important in terms of phenotypic outcome.

Thanks

Answer 1

[Devon Ryan]

All variants can get lost in subsequent generations, that doesn't change how functionally important they may or may not be. Any functionally relevant variant will experience pressure.

The importance of conserved/non-conserved regions when thinking of variants is that variants in conserved regions are more likely to be functionally relevant. The reason for this is that conserved regions are themselves more likely to be functionally relevant, since otherwise there'd be minimal pressure to conserve their sequence.

[muralinmars]

thanks for the explanation