Applications are invited for a 3-year MRC-funded postdoctoral research position in protein structural computational biology at the MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh.
This post will involve computationally investigating the relationships between protein complex structure and assembly, and human genetic variation and disease. Our early work suggests that the structure and assembly of protein complexes can strongly influence the phenotypic impacts of both protein-coding and non-coding variants. The goal of this project will be to first investigate this in much more detail, exploring how the assembly of proteins into complexes affects genotype-phenotype relationships for both Mendelian disease and complex traits. We will then seek to utilise this knowledge to improve predictions of mutation phenotype and prioritisation of causal variants.
The successful candidate will have a strong background in computational biology, with the ability to integrate and analyse large protein structural and genomic variation datasets. Applicants should have (or be close to having) a PhD in a relevant biological, biochemical or computational discipline.
Candidates are invited to contact Dr Joe Marsh at joseph.marsh@igmm.ed.ac.uk to discuss the post in more detail.
Ref: 033420
Closing Date: 6 July 2015
For more information and to submit an application, please use the 'apply' button below.
Link: https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=033420
