Is there some databases can predict the function of miRNA
2
2
Entering edit mode
6.4 years ago
zihuguo1986 ▴ 30

I have get a series of differential expressed miRNA from the microArray between the disease people and normal people. Now I want to study the function of the miRNAs, is there a website or database just like DAVID on which I could get the function or pathway enrichment miRNAs conviently. 

mirna function predict • 3.3k views
ADD COMMENT
0
Entering edit mode

Unfortunately, it seems that there is not such complete databases for miRNAs. Maybe its reason is that in most of applications, researchers map miRNAs to a list of target genes, then study the function of target genes. However, if google "miRNA database" you can find some databases such as miR2Disease.

ADD REPLY
0
Entering edit mode

oh, what a pity. Thank you very much.

ADD REPLY
2
Entering edit mode
5.7 years ago
Thomas ▴ 110

You could do it indirectly by looking at where the miRNA binds, and applying some method to determine the function of the miRNA target. You can identify predicted targets using resources such as  http://microrna.org and Targetscan (http://www.targetscan.org/)
 

So essentially you would be mapping your set of miRNAs to a set of mRNAs, which you would then map to a list of functions and/or pathways. I am less sure about the last step, maybe Gene ontology (GO) enrichment analysis?

ADD COMMENT
0
Entering edit mode
5.4 years ago
netbofia ▴ 20

There is this database that has published information on miRNAs called miRBase: http://mirbase.org This can be helpful if those miRNA found are in it.

However I'm no certain if this is still being maintained. But has a lot of information still.

ADD COMMENT

Login before adding your answer.

Traffic: 2006 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6