Question: What is the difference between fine-mapping and targeted sequencing?
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gravatar for genetic
3.9 years ago by
genetic40
United States
genetic40 wrote:

As far as I understand, targeted sequencing is for examine entire region of genes, and fine-mapping is examine certain GWAS loci. Can I say that fine-mapping is kind of targeted sequencing?

Thank you,

sequencing snp next-gen • 1.5k views
ADD COMMENTlink modified 3.9 years ago • written 3.9 years ago by genetic40
3
gravatar for Ying W
3.9 years ago by
Ying W3.9k
South San Francisco, CA
Ying W3.9k wrote:

Ehh, not really. My understanding is as follows:

Fine mapping is to go from tag SNPs in GWAS to identifying the causal SNPs

Targeted sequencing is a generic term to use some kind of capture technology to enrich for certain part of the genome before doing sequencing.

Its more accurate to say that you can use targeted sequencing for fine mapping.

ADD COMMENTlink written 3.9 years ago by Ying W3.9k
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gravatar for genetic
3.9 years ago by
genetic40
United States
genetic40 wrote:

Thank you for the clarification!

ADD COMMENTlink written 3.9 years ago by genetic40

If you are happy with that response, please click on the accept answer button on the left side of my answer to indicate that your question was resolved.

ADD REPLYlink written 3.9 years ago by Ying W3.9k
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