I am analyzing exome sequencing data for bladder cancer.
I ran somatic mutation detection tools and got a hundred of mutations in my storage. In order to classify which genes harboring variants are the most critical to target cancer, I think that genes that the most recurrently detected from my samples are the one that have the most dominant effects in my analysis. (Of course, I already removed any artifacts or non-relevant mutations).
It is very obvious that the most frequently mutated genes are the most important to corresponding cancer.
However, I tried to find relevant paper that are able to prove my evidence, but I can't.
I would appreciate it if someone who already have relevant article or paper about my issue, share with me the information.