Question: How to find appropriate control regions for gene burden tests on T-cell enhancer regions
gravatar for Vincent Laufer
3.1 years ago by
United States
Vincent Laufer980 wrote:


I study autoimmune disease. Recently, several groups have reported that T-cell enhancer regions are particularly enriched for candidate causal variants of Rheumatoid Arthritis and other autoimmune diseases.

I did covariate controlled gene burden testing on T-cell enhancer regions near to genes of interest in RA, and obtained some interesting results.

However, I want to run gene burden testing on a series of control regions.

My thought was that these control regions should be non-immune cell enhancer regions near non-immune cells, but in areas matching the loci I selected in other respects.

Does anyone have suggests on what to match for in selecting controls to see if there is inflation in test statistics?

Thank you very much!

gene-burden control enhancer • 992 views
ADD COMMENTlink modified 3.1 years ago • written 3.1 years ago by Vincent Laufer980
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