Question: Looking for Jewish Exoms
0
gravatar for nayshool
4.0 years ago by
nayshool20
Israel
nayshool20 wrote:

We are studying neurodegenerative disease using next generation sequencing on Jewish population.

I am looking for control group contain exomes of healthy Jewish samples (especially from Ashkenazi or North Africa origin).

Does anyone knows about such database which available to download? I looked at the ExAC 0.3 cohort, but it's divided into general population such Latino, Non-Finish European, Asian, etc.

 

thank you very much,

 

Omri

database jewish exome • 1.2k views
ADD COMMENTlink modified 3.9 years ago • written 4.0 years ago by nayshool20
1

I am not aware of such data set but maybe you can try and do a PCA analysis to find an available population that is less stratified from your samples? It won't be perfect but should at least give you somewhere to start working on 

ADD REPLYlink written 4.0 years ago by Sam2.3k
1

http://alfred.med.yale.edu/alfred/AboutALFRED.asp has some Jewish pops AFAICR, but there are not 1kg levels of SNPs there, so you would have to rely on linkage in some way.

These are not exomes either, rather SNP frequencies.

ADD REPLYlink written 4.0 years ago by Endre Bakken Stovner880

thank you all ffor your kind help!

ADD REPLYlink written 3.9 years ago by nayshool20
4
gravatar for rbagnall
4.0 years ago by
rbagnall1.4k
Australia
rbagnall1.4k wrote:

Not quite exomes, but the Ashkenazi Genome Consortium.

"We have recently released high-depth, whole genome sequence data on our initial sample of 128 healthy individuals from the Ashkenazi population"

http://ashkenazigenome.org/about/

Their paper

http://www.nature.com/ncomms/2014/140909/ncomms5835/full/ncomms5835.html

The VCF file is accessible at the European Genome-phenome Archive, although you need to apply to access the data

https://www.ebi.ac.uk/ega/studies/EGAS00001000664

ADD COMMENTlink modified 4.0 years ago • written 4.0 years ago by rbagnall1.4k
0
gravatar for aritra90
3.9 years ago by
aritra9040
United States
aritra9040 wrote:

You can look at this as well: 

http://evolbio.ut.ee/khazar/ for Ashkenazi studies and also the Jewish data from the same link. 

 

Hope this helps.

ADD COMMENTlink written 3.9 years ago by aritra9040
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