Question: How can I calculate selective pressure with opal mutations?
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wangyang703092 • 90 wrote:
Hi guys, I have a list of protein coding DNA sequences to calculate dN/dS but some of these have mutations which introduce a premature stop codon. So, how to calculate the ratio, just use the sequence before the stop codon or just delete the stop codon? And, is this mutation a mark of strong positive selection?
How can I calculate selective pressure with opal mutations?