What is the best aCGH normalization method for hyper-ploid tumor samples?
0
1
Entering edit mode
6.8 years ago

Hi people,

I'm currently working on aCGH data of Triple Negative Breast Cancer patients xenografts and primary tumor samples. A substantial amount of my samples is highly aberrated which leads to offsets of the diploid bands away from the log2ratio of 0.

I found an article on a prospective normalization for this: http://www.biomedcentral.com/1471-2164/8/382/ which includes the popLowess package in R: http://baseplugins.thep.lu.se/wiki/se.lu.onk.popLowess

However this a method from 2007 and I was wondering whether other approaches now exist that perhaps perform better (or different) aCGH normalizations. Ideas are very much welcome, thanks.

Greetings,

Sjors van Heuveln

aCGH normalization cancer hyperploid copy-number • 1.4k views
ADD COMMENT

Login before adding your answer.

Traffic: 1096 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6