Sample size too small for ARACNE
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6.5 years ago
grayapply2009 ▴ 240

The minimum sample size for ARACNE is 100 but I only have 20 samples. Can I resample each of my samples to make my overall sample size bigger? If so, what is the best way to do resampling?

ARACNE sample size • 2.0k views
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That doesnt sound like a good idea.

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What are species/tissue and a number of genes in the pathway? Can you tell more about these 20 samples and the experiment? What is the goal or idea of the study?

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Thank you very much for replying my post. There is a computer algorithm (ARACNE) that can reconstruct gene regulatory networks from gene expression profiles. However, it requires a minimum of 100 gene expression profiles, for example, 100 microarray datasets. I only have 20 of these datasets so I guess it cannot be done with such small datasets.

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? There are workarounds that realy depend on your dataset, specie, pathway you study and what for. Tell us your task and we all will think about it

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