Different between ab initio structural analysis and in silico homology modelling

Question

[Sarah Diana]

Hi,

I am doing my final year project. For my final year project I will continue my senior project on ab initio structural analysis. I am doing the homology modelling of the structure. I little bit confused with the different between the ab initio technique and in silico technique. So, can anyone explain what the different of technique used and the different between the structure produce by ab initio and in silico technique.

Thank you, :)

[venu]

It sounds a bit obscure (with sequencing, rna-seq tags). ab initio and homology modeling both are different. This is a good start to understand the difference between both. To make it simple in few words, Homology modeling is used to predict the structure of a protein based on the structure of its close relative (This relative is found by comparing its sequence with a sequence database) and ab initio method is used when we don't find any close relative.

[Sarah Diana]

thank you venu for the answer..