A Bioinformatics Analyst/Engineer position is available for a motivated, experienced computational scientist with a background in cancer biology and genomics. She/he will provide bioinformatics support to further the scientific initiatives in an expanding laboratory and research program at the University of California San Francisco (UCSF), within the Comprehensive Cancer Center. The Bivona lab is located at the UCSF Mission Bay Campus, a hub of academic and private-sector scientific discovery. The lab is directed by Trever Bivona MD, PhD (http://cancer.ucsf.edu/people/profiles/bivona_trever.3308) and is a vibrant and robust basic and translational research enterprise focused on improving the understanding of the molecular pathogenesis of human solid cancers and developing improved precision medicine approaches for better treating patients. The incumbent will support the development and utilization of next-generation sequencing applications to characterize the spectrum and biological and potential clinical significance of genetic alterations in human tumors. He/she will develop new and utilize existing software and database systems to track experimental parameters, catalyze technology development, and analyze next-generation sequence data. He/she will work with experimental and computational biologists, clinical and translational research collaborators, and scientists in the UCSF Helen Diller Comprehensive Cancer Center and beyond.
• Design, develop, and operate computational pipelines for the analysis of next-generation sequencing data,
• Analyze data sets to discover and annotate cancer-causing genetic mutations in tumor specimens and laboratory models, including design and analysis of cutting-edge functional genetic screening assays (e.g. CRISPR-based gene perturbation methods).
• Evaluate performance of novel technology platforms and assays.
• Work directly with the wet lab members of the research groups to analyze biomedical data and address scientific problems with bioinformatics techniques and tools and train researchers in the use of computational and bioinformatics tools.
• Develop, refine, and improve bioinformatics tools for interpretation of large genomic data sets.
• Evaluate and test third party software packages.
• Manage and archive large data sets from next-generation sequencing experiments
• Install and maintain software and data
• Maintain detailed records of all analyses
• Present results and progress updates at lab meetings and make presentations to experimental and scientific collaborators
• Attend seminars, lectures, and training courses to learn new computational biology skills to remain up to date with the cancer genomics field and learn new programming languages or techniques as necessary.
Master's degree or equivalent with at least 5 years of Bioinformatics software and system development required. PhD is strongly preferred. Cross-disciplinary and strong analytic skills, as well as broad experience with bioinformatics methods, databases, software, and computer programming languages are essential. The incumbent may lead and direct the work of others. US and Canadian citizens are encouraged to apply. Salary will be commensurate with experience, qualifications, and past performance. For inquires, please send a cover letter, CV, and 3 references to Dr. Trever Bivona (email@example.com).