Question: What does it mean a H4K20me1 has a diffuse profile?
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gravatar for tonja.r
3.3 years ago by
tonja.r430
UK
tonja.r430 wrote:

From the paper:

H2A.Z is representative of localized signals. H4K20me1 shows the typical behavior of chromatin modifications with a diffuse profile.

What does it mean a 'diffuse profile'?
Does it mean that the data (read coverage) for such modifications are not that striking as for ChIP-seq for TF?

  

chip-seq • 802 views
ADD COMMENTlink modified 3.3 years ago by Ming Tang2.4k • written 3.3 years ago by tonja.r430
2
gravatar for Ming Tang
3.3 years ago by
Ming Tang2.4k
Houston/MD Anderson Cancer Center
Ming Tang2.4k wrote:

TFs have specific binding DNA sequences. So the ChIP-seq signal will be sharp.

In comparison, histone modification can be broad (diffuse), extending to the gene body (H3K36me3 etc). 

RNApol2 can be both sharp(promoter stalling) and diffuse(elongation).

 

ADD COMMENTlink written 3.3 years ago by Ming Tang2.4k
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