What genes are associated with Fluorquinolone resistance of Mycobactaria tuberculosis beyond Gyrases A and B?
My data (WGS alignment and variant call computations) show that both clinically resistant and sensitive to Ofloxacin have almost the same DNA gyrase mutations in several reference positions (97%). GyrB occurs only in clinically resistant to Oflo therapy, however, cases are few (only 3 from 80). Need to know what more genes are considered to be responsible for Fluorquinolone resistance.
I am on the way of developing personalized decision and prescription system based on genomics data.