Dear Community,

I want to combine my normalized log2 intensity ratios (score column in bed file) of biological replicates from tiling array data set. These biological replicates are processed together and similarly normalized. I have understood that a simple arithmetic mean of the log2 intensity is the wrong way of combining replicates. As described in the literature http://www.sciencedirect.com/science/article/pii/S0092867405006458,

I want to use weighted average method to combine log2 intensities from biological replicates. I have no idea how to use this method, I would appreciate, any kind of guidance or suggestion.

Thanks