Entering edit mode
8.6 years ago
jotan
★
1.3k
I would like to check if I have ChIP-seq reads that map to repeats in the genome (e.g. LINEs, SINEs, telomeres, centromeres etc.) I use the Kharchenko lab repeat aligner to do this.
I intuitively feel as if an Input sequencing control is the best control since this should give an idea of the copy number of repeats within a single genome. However, I have noticed that some people use an IgG control instead.
Are there any thoughts on which control is better for alignments to repeats specifically?