Question: Software to calculate expected sequence identity between two species, given speciation time
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gravatar for Biomonika (Noolean)
4.4 years ago by
State College, PA, USA
Biomonika (Noolean)3.1k wrote:

I have two species, let's say one of them is human and second is one of the species of monkeys. If I align the homologous sequences between these two species, what's the expected sequence identity (given that I know speciation time as well as expected mutation rate)? Is there any software that would do this calculation for me?

I want to do this to verify that my alignments look reasonable.

 

ADD COMMENTlink written 4.4 years ago by Biomonika (Noolean)3.1k

Do you want to perform this calculation genome-wide, or just for certain genes? Mutation rates vary widely throughout the genome.

Do you have reason to suspect your alignment is fishy? I would do a "poor's man" test, checking if annotated features (coding regions particularly) show good agreement.

ADD REPLYlink written 4.4 years ago by h.mon29k
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