Binding Free Energy

Question

[Pratheep]

Hi to all, How much free energy needed for protein-protein or protein-drug interaction? How to identify active site of protein-drug interaction?

Answer 1

[Gjain]

hi,

this might be helpful to you.

1. Free Energy Decomposition of Protein-Protein Interactions
2. On the electrostatic component of protein-protein binding free energy
3. Protein–protein interactions: Making drug design second nature
4. A graphical model approach for predicting free energies of association for protein-protein interactions under backbone and side-chain flexibility
5. Predicting free energy changes using structural ensembles