Question: EVS non-reference variants for African-American
gravatar for reza.jabal
4.1 years ago by
New York, USA
reza.jabal350 wrote:

Hello Guys,

The 1000 Genomes consortium published a paper just couple of days ago on conclusion of the project in nature. According to them a typical genome differs from the reference human genome at 4.1 million to 5 million sites and along with that they produced a nice representation of variants frequency per populations.

As it is expected African populations show greatest number of variants in comparison to other populations, but I am wondering why in the "Exome Variant Server" number of variants for almost every sites is underrepresented for African-American population?

snp next-gen • 849 views
ADD COMMENTlink written 4.1 years ago by reza.jabal350

Can you re-phrase your question?  I'm interested, but don't quite understand what you are trying to resolve. 

ADD REPLYlink written 4.1 years ago by Zev.Kronenberg11k

sorry for badly written question. I am simply wondering why for each individual gene in EVS, number of variants that are indexed for African-American population is less than European-American population?

Consistent with "out of Africa model of human origins", we would expect greater number of variants per site in African descendant individuals. 

ADD REPLYlink written 4.1 years ago by reza.jabal350
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