The dilemna: I am submitting a grant proposal tomorrow morning. However, inspiration hit this morning and I need to make a new figure on short notice.
The need: My new figure will describe a well-annotated biological pathway. Here are the specific requirements:
- 10-20 pathway members
- edges must define functional relationships, not the experimental or analytical technique used to determine the edge (e.g., yeast two hybrid, co-expression, literature cooccurrence)
- functional edge types that are wanted include (but are not limited to):
- Transcriptional activation/repression
- Protein cleavage
- Other physical interaction
Note, I'm not looking for someone to identify pathway members, then pull out edges from PPI/coexpression databases. I'm looking for an expert-curated pathway diagram, perhaps from a review article on the topic or perhaps one of the curated pathway databases.
Edit: Networks do not need to be annotated with rate constants and the like. I am interested a qualitative description of a gene network...
Edit: Ideally, I'm looking for a network that has multiple edge types listed above...
The reward: Recognizing the urgency of my request, I'm mortgaging another 250 reputation points for the best answer. However, only answers in the next six hours are eligible. (Note the bounty will be entered in the system as soon as I'm able -- after a few days I think. But again, I need your answers now!)
The bonus: I will add an additional 100 reputation points to the bounty if the pathway is specifically on the Regulatory T cell differentiation pathway.