Hello biostars ,
I'm new to rna-seq and i'm trying to introduce myself to DESeq2.
My question is : why do we need to shrink the fold change and dispersion for RNA-seq data ?
Thanks in advance
I'd recommend trying to read the DESeq2 paper from 2014 (we wrote it with non-statisticians in mind), but you might also try this post on another thread:
A: Can someone please explain in simple terms how DESeq2 works?