Question: Is it possible to do linkage analysis using relatives from a family, without any trios or siblings ?
gravatar for Veera
3.4 years ago by
Veera 90
Veera 90 wrote:

I am trying to do some linkage analysis using exome sequencing data. I have exome data of three people from the same family (two first cousins and one second cousin). All are affected. I tried to create merlin input files using linkdatagen perl script. Now I am wondering if really linkage analysis can be done using merlin with a data that has no siblings or trios. Please input your suggestions. Thank you. 


merlin exome linkage • 1.2k views
ADD COMMENTlink modified 3.4 years ago • written 3.4 years ago by Veera 90

Linkage analysis works fine for large families.  That said, with only 3 individuals, your power will likely be VERY low.

ADD REPLYlink written 3.4 years ago by Sean Davis25k

merlin says that I have uninformative family. Can you tell how should I make a pedigree file in such situation ? The two cousins have same grand father and grand mother but different parents. But how can i put that information in the ped file.

ADD REPLYlink written 3.4 years ago by Veera 90
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