Entering edit mode
8.5 years ago
Veera
▴
90
I am trying to do some linkage analysis using exome sequencing data. I have exome data of three people from the same family (two first cousins and one second cousin). All are affected. I tried to create merlin input files using linkdatagen perl script. Now I am wondering if really linkage analysis can be done using merlin with a data that has no siblings or trios. Please input your suggestions. Thank you.
Linkage analysis works fine for large families. That said, with only 3 individuals, your power will likely be VERY low.
merlin says that I have uninformative family. Can you tell how should I make a pedigree file in such situation ? The two cousins have same grand father and grand mother but different parents. But how can i put that information in the ped file.