Is it possible to do linkage analysis using relatives from a family, without any trios or siblings ?
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5.5 years ago
Veera ▴ 90

I am trying to do some linkage analysis using exome sequencing data. I have exome data of three people from the same family (two first cousins and one second cousin). All are affected. I tried to create merlin input files using linkdatagen perl script. Now I am wondering if really linkage analysis can be done using merlin with a data that has no siblings or trios. Please input your suggestions. Thank you. 

 

merlin linkage exome • 1.7k views
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Linkage analysis works fine for large families. That said, with only 3 individuals, your power will likely be VERY low.

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merlin says that I have uninformative family. Can you tell how should I make a pedigree file in such situation ? The two cousins have same grand father and grand mother but different parents. But how can i put that information in the ped file.

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